Ro 48-8071 from CAYMAN CHEMICAL COMPANY
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| Product Name | Ro 48-8071 |
| Description | An oxidosqualene cyclase inhibitor with cholesterol lowering activity; inhibits OSC from human liver microsomes and HepG2 cells (IC50s = ~6.5 and ~1.5 nM, respectively); lowered LDL cholesterol ~40% in hamsters without affecting HDL levels and no sign of liver toxicity at 150 µg/kg; increases cytochrome P3A mRNA and protein levels in primary rat and murine hepatocyte cultures at 30 µM |
| Size | 100 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | monooxidosqualenes cyclases inhibitors OSC cholesterols lowering activity microsomal enzymes catalyzes lanosterol synthetic pathway LDL low-density lipoproteins human livers microsomes HepG2 cells HDL high-desity toxicity CYP3A mRNA proteins hepatocytes cultures atherosclerosis |
| Gene, Accession, CAS # | CAS: 161582-11-2 |
| Catalog # | 10006415-100 |
| Price | $561 |
| Order / More Info | Ro 48-8071 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY