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Product Name | Epalrestat |
Description | An aldose reductase inhibitor (IC50s = 0.01 and 0.26 µM for rat lens and human placenta aldose reductase, respectively); inhibits glucose-induced sorbitol accumulation in isolated rat lens, rat sciatic nerve, and human erythrocytes (IC50s = 1.5, 5, and 1.5 µM, respectively); decreases high glucose-induced proliferation of vascular smooth muscle cells at 10 nM and prevents high glucose-induced intracellular NADH/NAD+ increases and membrane-bound PKC activation at 100 nM; improves motor nerve conduction velocity and decreases sorbitol content in the sciatic nerve and erythrocytes in a rat model of streptozotocin-induced diabetic neuropathy at 20 and 40 mg/kg; prevents capillary strand formation in a rat model of diabetes-induced retinal microangiopathy at 50 mg/kg |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | ONO-2235 |
Gene, Accession, CAS # | CAS: 82159-09-9 |
Catalog # | 15214-25 |
Price | $198.00 |
Order / More Info | Epalrestat from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |