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Product Name | BMS 986165 |
Description | An allosteric inhibitor of TYK2 (IC50 = 0.2 nM for the recombinant TYK2 pseudokinase domain); selective for TYK2 over a panel of 249 protein and lipid kinases at 1 µM but does inhibit the JAK1 pseudokinase domain and BMPR2 (IC50s = 1 and 193 nM, respectively); inhibits IFN-α-induced phosphorylation of STAT1, -2, -3, and -5 in PBMCs (IC50s = 1-6 nM); inhibits IL-12-induced production of IFN-γ in human PBMCs (IC50 = 11 nM) and IL-12-induced phosphorylation of STAT4 in NK-92 cells (IC50 = 5 nM); has anti-inflammatory effects in various mouse models |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | antiinflammatory BMS986165 TYK IL12 IL18 IFIT-3 IFIT-1 |
Gene, Accession, CAS # | CAS: 1609392-27-9 |
Catalog # | 33524-1 |
Price | $44.00 |
Order / More Info | BMS 986165 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |