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Product Name | Asciminib |
Description | An allosteric inhibitor of Abl1 (IC50 = 0.45 nM); selective for Abl1 over a panel of more than 60 additional kinases (IC50s = >10 µM), as well as ion channels, nuclear receptors, GPCRs, and transporters; inhibits the proliferation of Luc-Ba/F3 cells transformed with wild-type Bcr-Abl1 or the drug-resistant mutant Bcr-Abl1T315I (GI50s = 1 and 25 nM, respectively), as well as other drug-resistant mutants; reduces tumor growth in a KCL-22 CML mouse xenograft model at 3 mg/kg twice per day and induces tumor regression at ≥7.5 mg/kg twice per day |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | ?ABL001 |
Gene, Accession, CAS # | CAS: 1492952-76-7 |
Catalog # | 26126-5 |
Price | $254.00 |
Order / More Info | Asciminib from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |