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Product Name | PLX5622 (hemifumarate) |
Description | A brain-penetrant CSF1R inhibitor (IC50 = 0.016 µM); selective for CSF1R over FLT3, Kit, Aurora C, and VEGFR2 (IC50s = 0.39, 0.86, 1, and 1.1 µM, respectively); greater than 100-fold selective for CSF1R over a panel of 230 kinases; reduces the number of Iba-1+ cells in the spinal cord dorsal horn in a mouse model of neuropathic pain induced by partial ligation of the sciatic nerve at 65 mg/kg; decreases macrophage levels of TNF-α and IL-1β and infiltration in the sciatic nerve and alleviates mechanical and cold allodynia in the same model; decreases the number of hippocampal microglia by 90%, as well as reduces the number and volume of retrosplenial and somatosensory cortical Aβ plaques in the 5XFAD mouse model of Alzheimer's disease at 1,200 ppm in the chow |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 1303420-67-8 2749102-07-4 PLX 5622 CSF 1R VEGFR 2 TNFα IL1β 5X FAD |
Gene, Accession, CAS # | n/a |
Catalog # | 36277-10 |
Price | $184 |
Order / More Info | PLX5622 (hemifumarate) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |