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Product Name | NCS-382 (sodium salt) |
Description | A GHBR antagonist (IC50s = 134.1 and 201.3 nM in isolated rat striatal and hippocampal membranes, respectively, in radioligand binding assays); selective for GHBR over GABA binding sites in rat brain synaptic membranes at 1 and 10 µM; decreases GHB-induced increases in inositol phosphate accumulation and cGMP levels in isolated rat hippocampal slices (IC50s = 8.6 and 30 µM, respectively); reduces GHB-induced increases in the time mice spent immobile in the forced swim test at 1.66 and 2.08 mmol/kg; decreases spike and wave discharges in audiogenic seizure-susceptible Swiss Rb mice, as well as a rat model of petit mal epilepsy, at 2.3 mmol/kg |
Size | 50 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 520505-01-5 NCS382 antisedative |
Gene, Accession, CAS # | CAS: 131733-92-1 |
Catalog # | 29315-50 |
Price | $412.00 |
Order / More Info | NCS-382 (sodium salt) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |