AS-2444697 (hydrochloride) from CAYMAN CHEMICAL COMPANY
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| Product Name | AS-2444697 (hydrochloride) |
| Description | An IRAK4 inhibitor (IC50 = 21 nM); greater than 30-fold selective for IRAK4 over a panel of 146 kinases, but is less than 10-fold selective over PDGFRα, PDGFRβ, TrkA, TrkC, CLK1, Itk, and FLT3; inhibits IL-1β-induced IL-6 production and LPS-induced TNF-α production in cellular assays (IC50s = 250 and 47 nM, respectively); efficacious in rat models of adjuvant- and collagen-induced arthritis (ED50s = 2.7 and 1.6 mg/kg, respectively); reduces urinary protein excretion, the development of interstitial fibrosis and glomerulosclerosis, and renal mRNA expression of genes encoding IL-1β, IL-6, TNF-α, and CCL2 in the 5/6 nephrectomized rat model of chronic kidney disease from 0.3-3 mg/kg |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 1287665-58-0 IRAK-4 interleukin1 Trk-A C CLK-1 FLT-3 IL1β IL6 glomerulo sclerosis TNFα |
| Gene, Accession, CAS # | CAS: 1287665-60-4 |
| Catalog # | 29505-1 |
| Price | $34.00 |
| Order / More Info | AS-2444697 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY