EPI-001 from CAYMAN CHEMICAL COMPANY
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| Product Name | EPI-001 |
| Description | An androgen receptor antagonist (IC50 = ~6 µM for inhibition of transactivation of the androgen receptor NTD); inhibits androgen-, FSK-, and IL-6-induced, as well as ligand-independent, PSA reporter gene expression in LNCaP cells expressing either the full length androgen receptor or a constitutively active mutant that lacks the ligand binding domain in a dose-dependent manner; inhibits androgen receptor interaction with the PSA androgen response element and blocks androgen-stimulated induction of endogenous PSA and 17 other androgen regulated genes in LNCaP cells; inhibits androgen-dependent and -independent growth of LNCaP and MDA-PCa-2B cells, but not 22Rv1, DU145, or PC3 cells that do not express the androgen receptor; reduces serum PSA and tumor growth in an LNCaP prostate cancer xenograft model in castrated mice when administered at a dose of 50 mg/kg, |
| Size | 25 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 882690-01-9 1297605-27-6 EPI001 ?H2O IL6 MDAPCa2B DU-145 PC-3 LT-313 |
| Gene, Accession, CAS # | CAS: 227947-06-0 |
| Catalog # | 16970-25 |
| Price | $166.00 |
| Order / More Info | EPI-001 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY