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Product Name | Corynoline |
Description | An isoquinoline alkaloid with diverse biological activities; an inhibitor of acetylcholinesterase (IC50 = 30.6 µM); an inhibitor of BACE1 (IC50s = 33.59 and 89.07 µM for FRET and immobilized enzyme reactive assays, respectively); decreases LPS-induced NF-κB activation and reverses LPS-induced decreases in Nrf2 and HO-1 protein levels in HUVECs; increases the survival rate in a mouse model of LPS- and heat-killed E. coli-induced sepsis at 10, 20, and 40 mg/kg; selectively inhibits proliferation of B16/F10 mouse and A375 human melanoma cells (IC50s = 12.87 and 10.47 µM, respectively) over non-cancerous melanocytes (IC50 = 126.61 µM); reduces tumor growth in a B16/F10 mouse melanoma model at 20 mg/kg |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | (+)-Corynoline|(d)-Corynoline|13-methyl-Chelidonine|CRL |
Gene, Accession, CAS # | CAS: 18797-79-0 |
Catalog # | 30712-10 |
Price | $263.00 |
Order / More Info | Corynoline from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |