CP 99,994 (hydrochloride) from CAYMAN CHEMICAL COMPANY
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| Product Name | CP 99,994 (hydrochloride) |
| Description | A nonpeptide NK1 receptor antagonist (Ki = 0.25 nM in a radioligand binding assay); selective for NK1 over NK2 and NK3 receptors (Kis = >10 µM for both); inhibits excitation of guinea pig locus coeruleus cells induced by substance P in vitro (IC50 = 25 nM); inhibits increases in horizontal locomotor activity induced by [Sar9,Met(O2)11]-substance P in guinea pigs (ID50 = 0.59 mg/kg); inhibits aerosolized capsaicin-induced plasma extravasation in guinea pig lung (ID50 = 4 mg/kg); exhibits anti-emetic effects in ferret models of emesis induced by copper sulfate, loperamide, or cisplatin at 0.3 and 1 mg/kg |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 136982-36-0 CP99994 CP99,994 HCl 99994 NK 1 2 3 D α antiemetic cavy |
| Gene, Accession, CAS # | CAS: 145148-39-6 |
| Catalog # | 27669-5 |
| Price | $139.00 |
| Order / More Info | CP 99,994 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY