MK-7246 from CAYMAN CHEMICAL COMPANY
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| Product Name | MK-7246 |
| Description | A CRTH2/DP2 receptor antagonist (Ki = 2.5 nM); selective for CRTH2/DP2 over DP1, FP, IP, and TP receptors (Kis = 373, >25,100, >23,030, and 3,804 nM, respectively), as well as EP1-4 (Kis = 7,668-23,330 nM); inhibits 13,14-dihydro-15-keto-PGD2-induced inhibition of cAMP formation in HEK293 cells expressing human CRTH2/DP2 (IC50 = 3 nM); inhibits 13,14-dihydro-15-keto-PGD2-induced eosinophil shape change (IC50 = 2.2 nM) and CD11b upregulation on eosinophils and basophils in isolated human whole blood (IC50s = 6.2 and 5.4 nM, respectively); decreases antigen-induced late-phase bronchoconstriction and completely prevents airway hyperresponsiveness in sheep at 1 mg/kg |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | MK7246 HEK 293 CD 11b |
| Gene, Accession, CAS # | CAS: 1218918-62-7 |
| Catalog # | 34208-1 |
| Price | $89.00 |
| Order / More Info | MK-7246 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY