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Product Name | NSC 207895 |
Description | An inhibitor of MDMX; decreases MDMX promoter activity in a reporter assay in a concentration-dependent manner; decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX at 5 µmol/L; induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner at 5 µmol/L; induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively) |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | NSC 179940|XI-006 |
Gene, Accession, CAS # | CAS: 58131-57-0 |
Catalog # | 27949-5 |
Price | $252.00 |
Order / More Info | NSC 207895 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |