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Product Name | TG101348 |
Description | A JAK2 inhibitor (IC50 = 3 nM for wild-type and JAK2V617F enzymes); is 35-, 334-, and 135-fold selective for JAK2 over JAK1, JAK3, and TYK2, respectively; selective for JAK2 over a panel of 34 kinases at 500 nM; inhibits FLT3 and RET (IC50s = 15 and 48 nM, respectively); reduces the proliferation of HEL cells as well as Ba/F3 murine cells expressing JAK2V617F (IC50s = 305 and 270 nM, respectively); inhibits the differentiation of hematopoietic stem cells and myeloid progenitor cells isolated from patients with polycythemia vera at 300 nM; improves survival and reduces spleen weight in a syngeneic mouse model of polycythemia vera induced by transplantation of Jak2V617F-expressing whole bone marrow at 60 and 120 mg/kg |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | Fedratinib|SAR302503 |
Gene, Accession, CAS # | CAS: 936091-26-8 |
Catalog # | 16289-10 |
Price | $187.00 |
Order / More Info | TG101348 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |