Difamilast from CAYMAN CHEMICAL COMPANY
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| Product Name | Difamilast |
| Description | A PDE4 inhibitor; selective for the PDE4 isoforms PDE4A, PDE4B, PDE4C, and PDE4D (IC50s = 0.0832, 0.0112, 0.2493 and 0.0738 µM, respectively) over PDE5A and PDE10A (IC50s = 4.793 and 1.4346 µM, respectively) and eight other PDEs (IC50s = >10 µM for all); increases intracellular cAMP levels in U937 cells at 0.01-10 µM; inhibits LPS-induced increases in TNF-α secretion from isolated human and mouse PBMCs (IC50s = 19 and 3.5 nM, respectively); decreases ear thickness and CD3+ T cell, eosinophil, and neutrophil lesion infiltrates in a mouse model of 2,4,6-trinitrochlorobenzene-induced chronic allergic contact dermatitis when applied topically at 3% w/v |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | OPA 15406 |
| Gene, Accession, CAS # | CAS: 937782-05-3 |
| Catalog # | 39664-10 |
| Price | $563.00 |
| Order / More Info | Difamilast from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY