Epalrestat from CAYMAN CHEMICAL COMPANY
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| Product Name | Epalrestat |
| Description | An aldose reductase inhibitor (IC50s = 0.01 and 0.26 µM for rat lens and human placenta aldose reductase, respectively); inhibits glucose-induced sorbitol accumulation in isolated rat lens, rat sciatic nerve, and human erythrocytes (IC50s = 1.5, 5, and 1.5 µM, respectively); decreases high glucose-induced proliferation of vascular smooth muscle cells at 10 nM and prevents high glucose-induced intracellular NADH/NAD+ increases and membrane-bound PKC activation at 100 nM; improves motor nerve conduction velocity and decreases sorbitol content in the sciatic nerve and erythrocytes in a rat model of streptozotocin-induced diabetic neuropathy at 20 and 40 mg/kg; prevents capillary strand formation in a rat model of diabetes-induced retinal microangiopathy at 50 mg/kg |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | ONO-2235 |
| Gene, Accession, CAS # | CAS: 82159-09-9 |
| Catalog # | 15214-10 |
| Price | $88.00 |
| Order / More Info | Epalrestat from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY