RVX-297 from CAYMAN CHEMICAL COMPANY
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| Product Name | RVX-297 |
| Description | A BD2 bromodomain inhibitor; inhibits BD2 in BRD2, BRD3, and BRD4 (IC50s = 0.08, 0.05, and 0.02 µM, respectively) and is selective for BD2 over BD1 (IC50s = 3.76, 2.34, and 1.16 µM for BRD2, BRD3, and BRD4, respectively), as well as CREBBP and p300 (IC50s = >50 µM for both); decreases levels of the mRNAs encoding IL-6 and VCAM-1 in primary synovial fibroblasts isolated from patients with rheumatoid arthritis at 10 and 30 µM; It prevents LPS-induced increases in IL-6 and Ifn-γ serum levels in a mouse model of LPS-induced endotoxemia at 75 mg/kg; inhibits collagen-induced increases in ankle and knee diameter, cartilage damage, the ankle tissue levels of mRNAs encoding IL-1β, Mmp-3, Mmp-13, and Rankl, and ankle joint protein levels of IL-6 and VCAM-1 in a rat model of collagen-induced rheumatoid arthritis at 25, 50, and 75 mg/kg twice per day; improves gait and mobility and reverses body weight loss, as well as decreases the number of spinal cord inflammatory foci and apoptotic cells and reduces spinal nerve demyelination in a mouse model of EAE at 75 and 125 mg/kg per day |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | RVX297 BD BRD p-300 interleukin IL6 VCAM1 m-RNA messanger RA Ifnγ Il1β Mmp3 Mmp13 Vcam1 |
| Gene, Accession, CAS # | CAS: 1044871-04-6 |
| Catalog # | 38777-10 |
| Price | $143.00 |
| Order / More Info | RVX-297 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY