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Product Name | NSC 23925 |
Description | An inhibitor of P-gp; selectively reverses multidrug resistance mediated by P-gp over MRP1- and BCRP-mediated multidrug resistance; resensitizes SKOV3TR and OVCAR-8TR cells to paclitaxel; reverses P-gp efflux, increasing the intracellular accumulation of P-gp substrates in multidrug resistant SKOV3TR and OVCAR-8TR cells; prevents paclitaxel-induced overexpression of MDR1 and P-gp protein level increases in OVCAR-8 cells; prevents the development of paclitaxel-induced multidrug resistance in a SKOV3 mouse xenograft model at 50 mg/kg per day in combination with paclitaxel |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 19287-55-9 NSC23925 multi-drug MRP-1 ABCC-1 SKOV-3 OVCAR8 MDR-1 PgP |
Gene, Accession, CAS # | CAS: 858474-14-3 |
Catalog # | 21947-1 |
Price | $36.00 |
Order / More Info | NSC 23925 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |