NS 11394 from CAYMAN CHEMICAL COMPANY
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| Product Name | NS 11394 |
| Description | A positive allosteric modulator of the GABAA receptor (Ki = 0.423 nM); selective for GABAA receptors containing α1, α2, α3, or α5 subunits (Kis = 0.41, 0.84, 0.497, and 0.119 nM, respectively) over receptors containing α4 or α6 subunits (Kis = 324 or 1,009 nM, respectively); modulator of GABA receptors containing subunits α3 and α5 with maximal potentiation rates of 52% and 78%, respectively, relative to diazepam; inhibits [3H]flunitrazepam binding to benzodiazepine receptors in mouse and rat forebrain in vivo (EC50s = 0.38 and 1.3 mg/kg, respectively, at 30 minutes and 0.49 and 0.69 mg/kg, respectively, at 120 minutes following oral administration); attenuates spontaneous nociceptive behaviors in a rat model of neuropathic pain when administered at doses of 1-30 mg/kg |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | NS11394 gamma-aminobutyric acid gaba-a a1 a2 a3 a4 a5 a6 Xenopus |
| Gene, Accession, CAS # | CAS: 951650-22-9 |
| Catalog # | 23872-5 |
| Price | $139.00 |
| Order / More Info | NS 11394 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
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