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Product Name | KMN-80 |
Description | A selective, potent agonist of EP4 with an IC50 value of 3 nM (versus 1.4 µM for EP3 and > 10 µM for all other prostanoid receptors) and an EC50 value of 0.19 nM in functional assays; induces the differentiation of bone marrow stem cells from both young and aged rats into osteoblasts in vitro (EC50s = 20 and 153 nM, respectively); repairs calvarial defects in an in vivo rat craniomaxillofacial reconstruction model and promotes bone formation in a rat incisor tooth socket model |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | EP4 receptors agonists prostaglandins E2 PGE2 E1 PGE1 bones formations resorption marrow stem cells differentiation L-902,688 calvarial defect BMP2 bone regeneration bone matrix KMNs 80 KMN80 pyrrolidinone derivatives |
Gene, Accession, CAS # | CAS: 1628759-75-0 |
Catalog # | 15435-1 |
Price | $169.00 |
Order / More Info | KMN-80 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |