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Product Name | TCS 21311 |
Description | A JAK3 inhibitor (IC50 = 8 nM); selective for JAK3 over JAK1, JAK2, and TYK2 (IC50s = 1,017, 2,550, and 8,055 nM, respectively) but does inhibit GSK-3β, PKCα, and PKCθ (IC50s = 13, 68, and 3 nM, respectively); inhibits cytokine-induced STAT5 phosphorylation in CTLL and M-07 cells (IC50s = 1,294 and 525 nM, respectively) and TCR/CD28-mediated T cell activation in Jurkat cells (IC50 = 689 nM); increases proliferation of mouse embryonic NPCs and human iPSC-derived NPCs in the absence of BMP7 at 0.3 µM |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | NIBR3049 |
Gene, Accession, CAS # | CAS: 1260181-14-3 |
Catalog # | 30063-25 |
Price | $684.00 |
Order / More Info | TCS 21311 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |