K145 (hydrochloride) from CAYMAN CHEMICAL COMPANY
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| Product Name | K145 (hydrochloride) |
| Description | A selective inhibitor of SPHK2 (Ki = 6.4 µM; IC50s = 4.3 and >10 µM for human recombinant SPHK2 and SPHK1, respectively); inhibits SPHK2 activity in U937 cells at 10 µM; inhibits tumor growth in a U937 mouse xenograft model at 15 mg/kg; improves glucose tolerance and regulates gluconeogenesis by stimulating insulin-dependent Akt/FoxO1 signaling in a mouse model of dexamethasone-induced insulin resistance at 30 mg/kg |
| Size | 500 µg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 1313592-68-5 SphK-2 anticancer U-937 tamibarotene K-145 |
| Gene, Accession, CAS # | CAS: 1449240-68-9 |
| Catalog # | 11691-500 |
| Price | $32.00 |
| Order / More Info | K145 (hydrochloride) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY