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Product Name | NMS-1286937 |
Description | An inhibitor of Plk1 (IC50 = 2 nM); selective for Plk1 over Plk2 and Plk3 (IC50s = >10,000 nM for both); inhibits proliferation of A2780 cells (IC50 = 42 nM); halts the cell cycle at the G2/M phase in A2780 cells at 20-200 nmol/L and induces apoptosis; reduces tumor growth in an HCT116 mouse xenograft model at 60 mg/kg once per day; induces tumor regression in an HT-29 mouse xenograft model at 45 mg/kg in combination with CPT11 |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | NMS-P937|Onvansertib|PCM-075 |
Gene, Accession, CAS # | CAS: 1034616-18-6 |
Catalog # | 28762-10 |
Price | $169.00 |
Order / More Info | NMS-1286937 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |