MRK-016 from CAYMAN CHEMICAL COMPANY
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| Product Name | MRK-016 |
| Description | An inverse agonist of α5 subunit-containing GABAA receptors; selectively binds to α1-, α2-, α3-, and α5 subunit-containing GABAA receptors (Kis = 0.83, 0.85, 0.77, and 1.4 nM, respectively) over those containing α4 and α6 subunits (Kis = 395 and >4,000 nM, respectively); selectively inhibits GABA-induced currents in L-M(TK-) cells expressing α5 subunit-containing GABAA receptors over those containing α1, α2, or α3 subunits; reverses LPS-induced decreases in Bdnf expression in the mouse hippocampus at 3 mg/kg; reverses LPS-induced memory consolidation deficits in mice at 3 mg/kg; enhances the performance of wild-type rats in a delayed matching-to-place water maze at 0.3, 1, and 3 mg/kg; reduces immobility in the forced swim test |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 783331-24-8 MRK016 GABA-A Lipopolysaccharide MRK16 16 |
| Gene, Accession, CAS # | CAS: 342652-67-9 |
| Catalog # | 36656-5 |
| Price | $158.00 |
| Order / More Info | MRK-016 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
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http://www.caymanchem.com
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