M-3258 from CAYMAN CHEMICAL COMPANY
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| Product Name | M-3258 |
| Description | An LMP7 inhibitor (IC50 = 4.1 nM); selective over the 20S proteasomal catalytic subunits β1, -β2, and -β5 (IC50s = >10,000, 2,519, and >10,000 nM, respectively), as well as LMP2 and PSMB10 (IC50s = >10,000 nM for both); increases ubiquitinated protein levels (EC50 = 1,980 nM) and induces apoptosis in MM.1S cells (EC50 = 420 nM); reduces tumor volume in U266B1, OPM-2, and RPMI-8226 mouse xenograft models of multiple myeloma at 10 mg/kg per day |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | M3258 LMP 7 immuno proteasome sub unit multi functional pepti dase protea some LMP 2 PSM B10 ubiquit inated apop tosis MM.S mye loma U 266B1 OPM2 RPMI8226 |
| Gene, Accession, CAS # | CAS: 2285330-15-4 |
| Catalog # | 38160-5 |
| Price | $379.00 |
| Order / More Info | M-3258 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY