SR 3029 from CAYMAN CHEMICAL COMPANY
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| Product Name | SR 3029 |
| Description | An inhibitor of CK1δ and CK1ε (IC50s = 44 and 260 nM, respectively); selective for CK1δ and CK1ε over 438 kinases in a panel but also inhibits MYLK4, FLT3, Cdk4/cyclin D1, and MARK2 by >90% at 10 µM; inhibits Cdk4/cyclin D1, Cdk4/cyclin D3, Cdk6/cyclin D1, Cdk6/cyclin D3, and FLT3 (IC50s = 576, 368, 428, 427, and 3,000 nM, respectively); inhibits proliferation of A375 human melanoma cells in vitro (EC50 = 86 nM); reduces tumor growth and increases lifespan in MDA-MB-231 and MDA-MB-468 mouse xenograft models at 20 mg/kg per day; reduces the expression of the Wnt/β-catenin target CCND1 and decreases protein levels of nuclear β-catenin and cyclin D1 in mouse tumor tissue |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | SR3029 CK 1δ 1ε MYL K4 MYLK 4 FLT 3 Cdk MARK 2 6 A 375 MDAMB231 MB231 MDAMB MDAMB468 MB468 CCND |
| Gene, Accession, CAS # | CAS: 1454585-06-8 |
| Catalog # | 27048-5 |
| Price | $86.00 |
| Order / More Info | SR 3029 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY