Description | A prenylated flavonoid with diverse biological activities; inhibits UGT1A6, UGT1A7, and UGT1A8 (IC50s = 4.23, 0.98, and 3 µM, respectively); inhibits CYP3A4, CYP1A2, CYP2C9, and CYP2E1 (IC50s = 2.13, 1.27, 3.18, and 9.28 µM, respectively); inhibits A23187- and PMA-induced histamine and LTC4 production in mouse MC/9 mast cells at 4 µM; inhibits the growth of MCF-7, MDA?MB?231, and MDA?MB?453 breast cancer cells (IC50s = 13.53, 10.84, and 11.99 µM, respectively); decreases colonic tissue damage, TGF-β1 levels, and MMP-2 and MMP-9 activity in a rat model of TNBS-induced ulcerative colitis at 12.5 mg/kg per day |