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Product Name | Saikosaponin A |
Description | A triterpenoid saponin with diverse biological activities; reduces expression of TNF-α, IL-6, and IL-1β in LPS-stimulated primary mouse macrophages; increases the survival rate in mice with LPS-induced lethal endotoxemia; reduces weight loss, brain edema, blood-brain barrier disruption, and cortex IL-6 and TNF-α protein levels in the ipsilateral cortex in a rat model of traumatic brain injury at 20 mg/kg; reduces the number of nasal rubs and levels of serum TNF-α in an ovalbumin-sensitized allergic rhinitis mouse model in vivo at 8 mg/kg; reduces duration and frequency of epileptiform discharges in rat hippocampal CA1 neurons in a 4-AP seizure model; decreases viability in six HCC, H358 lung and MCF-7 breast cancer, as well as Jurkat and K582 leukemia cell lines at 20 µM; prolongs tumor growth inhibition in LoVo and SW480 HCC mouse xenograft models in vivo at 2 mg/kg |
Size | 5 mg |
Concentration | n/a |
Applications | n/a |
Other Names | Salikosaponin Oleanane SsA TNFα IL6 IL1β 4AP C-A1 H-358 MCF7 K-582 SW-480 antiinflammatory anti-allergic convulsive proliferative viral |
Gene, Accession, CAS # | CAS: 20736-09-8 |
Catalog # | 25026-5 |
Price | $116.00 |
Order / More Info | Saikosaponin A from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |