NSC 207895 from CAYMAN CHEMICAL COMPANY
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| Product Name | NSC 207895 |
| Description | An inhibitor of MDMX; decreases MDMX promoter activity in a reporter assay in a concentration-dependent manner; decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX at 5 µmol/L; induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner at 5 µmol/L; induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively) |
| Size | 25 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | NSC 179940|XI-006 |
| Gene, Accession, CAS # | CAS: 58131-57-0 |
| Catalog # | 27949-25 |
| Price | $911.00 |
| Order / More Info | NSC 207895 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
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Ann Arbor MI 48108
P: (734) 971-3335
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F: (734) 971-3640
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