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Product Name | DO264 |
Description | An ABHD12 inhibitor (IC50 = 11 nM); inhibits ABHD-dependent hydrolysis of lyso-PS in mouse brain membrane lysates (IC50 = 2.8 nM) and human THP-1 cells; increases levels of CCL3, CCL4, TNF-α, and IL-1β in M1-polarized THP-1 macrophages; increases levels of 1-stearoyl-2-hydroxy-sn-glycero-3-PS, 1-arachidonoyl-2-hydroxy-sn-glycero-3-PS, 1-docosanoyl-2-hydroxy-sn-glycero-3-PS, 1-stearoyl-2-arachidonoyl-sn-glycero-3-PS, and 1-oleoyl-2-arachidonoyl-sn-glycero-3-PS in mouse brain at 30 mg/kg per day for four weeks; increases levels of CCL2, CCL3, and CCL5 in BALF and decreases survival in a mouse model of infection with LCMV clone 13 at 30 mg/kg |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | DO-264 ABHD-12 lyso-phosphatidylserine phosphatidyl-serine lysophosphatidyl lysoPS CCL-3 4 5 2 TNFα IL1β M1polarized THP1 broncho-alveolar clone13 |
Gene, Accession, CAS # | CAS: 2301866-59-9 |
Catalog # | 29402-1 |
Price | $73.00 |
Order / More Info | DO264 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |