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Product Name | DL-threo-PDMP (hydrochloride) |
Description | An inhibitor of sphingolipid biosynthesis; inhibits glucosylceramide synthase by 33 and 48% in MDCK cell homogenates at 5 and 10 µM; reduces the synthesis of glucosylceramide increases cellular ceramide, and induces cell cycle arrest; increases Aβ42 and Aβ39 production independent of ceramide metabolism via modulation of γ-secretase activity |
Size | 50 mg |
Concentration | n/a |
Applications | n/a |
Other Names | analog analogue inhibit inhibitor cytotoxicity glucosylceramide synthase chirality stereoisomer sphingosine (±)PDMP ceramide cultured cell treatment cellular cycle arrest alkaline cereamidase isomer β-1,4-galactosyltransferase 6 lactosylceramide neuroinflammation promoter mice mouse chronic autoimmune encephalomyelitis multiple sclerosis MS |
Gene, Accession, CAS # | CAS: 80938-69-8 |
Catalog # | 10005276-50 |
Price | $199.00 |
Order / More Info | DL-threo-PDMP (hydrochloride) from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |