Voxtalisib from CAYMAN CHEMICAL COMPANY
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| Product Name | Voxtalisib |
| Description | A dual inhibitor of PI3K and mTORC (IC50s = 9, 110, 43, 9, 160, and 910 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, mTORC1, and mTORC2, respectively); is selective for these kinases over VPS34 (IC50 = 9,100 nM) and a panel of 130 additional protein kinases at 1.5 µM but does inhibit DNAPK (IC50 = 150 nM); decreases EGF-induced PIP3 production in PC3 prostate cancer cells (IC50 = 290 nM); reduces Akt and S6RP phosphorylation in the same model (IC50s = 250 and 120 nM, respectively); inhibits proliferation and colony formation of PC3 cells (IC50s = 1,800 and 270 nM, respectively); reduces tumor growth and increases survival in a GBM-39 mouse xenograft model at 30 mg/kg twice per day either alone or in combination with temozolomide |
| Size | 50 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | SAR245409|XL765 |
| Gene, Accession, CAS # | CAS: 934493-76-2 |
| Catalog # | 30323-50 |
| Price | $578.00 |
| Order / More Info | Voxtalisib from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY