ASP7657 from CAYMAN CHEMICAL COMPANY
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| Product Name | ASP7657 |
| Description | An EP4 antagonist (IC50s = 0.29 and 0.86 nM for the human and rat receptors, respectively); selective for these receptors over rat EP1, EP2, and EP3 receptors (IC50s = >1,000 nM for all), as well as a panel of 42 additional receptors and ion channels (IC50s = >1,000 nM for all); inhibits PGE2-induced increases in cAMP accumulation in Jurkat cells expressing human EP4 and CHO cells expressing the rat receptor (IC50s = 0.29 and 0.86 nM, respectively); inhibits PGE2-induced decreases in LPS-stimulated TNF-α release in isolated rat whole blood; decreases albuminuria in the db/db mouse model of type 2 diabetes at 0.01 and 0.1 mg/kg per day |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | EP 1 2 3 4 ASP 7657 PGE 2 TNFα lipopolysaccharide |
| Gene, Accession, CAS # | CAS: 1196045-28-9 |
| Catalog # | 28578-1 |
| Price | $68.00 |
| Order / More Info | ASP7657 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY