MRTX-849 from CAYMAN CHEMICAL COMPANY
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| Product Name | MRTX-849 |
| Description | A covalent inhibitor of K-RasG12C; binds to and stabilizes GDP-bound inactive K-RasG12C in an electrophoretic mobility shift assay from 2-15.6 nM; reduces phosphorylation of the K-Ras targets ERK and S6 in MIA PaCa-2 cancer cells from 33-1,000 nM; reduces tumor volume in 17 K-RasG12C-expressing lung, colon, pancreatic, cervical, and esophageal cancer mouse xenograft models at 100 mg/kg |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | MRTX849 KRas G12-C G-12C PaCa2 A-549 HCT-116 H-1299 S-6 |
| Gene, Accession, CAS # | CAS: 2326521-71-3 |
| Catalog # | 31440-10 |
| Price | $264.00 |
| Order / More Info | MRTX-849 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY