PRN-1371 from CAYMAN CHEMICAL COMPANY
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| Product Name | PRN-1371 |
| Description | An irreversible pan-FGFR inhibitor (IC50s = 0.7, 1.3, 4.4, and 19.3 nM for FGFR-1, -2, -3, and -4, respectively); selective for FGFR over VEGFR2 (IC50 = 705 nM) and a panel of 250 kinases (IC50s = >1 µM for all) but does inhibit CSF1R activity by >90% at 1 µM; inhibits proliferation in a panel of ten cancer cell lines containing various FGFR mutants (IC50s = 2-231 nM) and induces apoptosis in SNU-16 gastric and RT4 bladder cancer cells (EC50s = 15.9 and 11.8 nM, respectively); reduces tumor growth in an SNU-16 mouse xenograft model and a PDX mouse model of liver cancer at 15 mg/kg twice per day |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 1814961-21-1 PRN1371 panFGFR VEGFR 2 CSF 1R SNU16 RT 4 |
| Gene, Accession, CAS # | CAS: 1802929-43-6 |
| Catalog # | 33787-5 |
| Price | $257 |
| Order / More Info | PRN-1371 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
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