XL092 from CAYMAN CHEMICAL COMPANY
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| Product Name | XL092 |
| Description | A multi-kinase inhibitor; selectively inhibits MET, VEGFR2, Axl, and Mer (IC50s = 3, 15, 5.8, and 0.6 nM, respectively) over serine/threonine kinases for which it has no activity, but does inhibit 28 additional RTKs (IC50s = 3-54 nM) and additional kinases by greater than 70% at 1 µM; inhibits the proliferation of SNU-5 cells (IC50 = 98.9 nM) and HUVECs (IC50 = 10.4 nM); reduces tumor volume and intratumoral MET phosphorylation in NCI H441 and SNU-5 mouse xenograft models at 3 and 10 mg/kg; increases the number of peripheral B cells and CD4+ T cells, and decreases the number of peripheral myeloid cells, in an MC-38 syngeneic mouse model of colon carcinoma at 30 mg/kg |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | Zanzalintinib |
| Gene, Accession, CAS # | CAS: 2367004-54-2 |
| Catalog # | 37749-5 |
| Price | $78.00 |
| Order / More Info | XL092 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY