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Product Name | Tirasemtiv |
Description | An activator of the fast skeletal troponin complex; selectively binds to purified fast skeletal troponin complex (Kd = 40 nM) over slow skeletal (Kd = 3,800 nM) and cardiac troponin complexes; slows the rate of calcium release from the fast skeletal troponin complex at 20 µM; increases the ATPase activity of isolated rabbit fast skeletal myofibrils at a fixed calcium concentration (EC50 = 390 nM); sensitizes skinned fast skeletal muscle fibers isolated from human and rabbit to calcium; increases in situ EDL muscle force and forelimb grip strength in a rat model of myasthenia gravis; increases forelimb grip strength, grid hang test performance, and rotarod performance in a mouse model of ALS at 10 mg/kg |
Size | 50 mg |
Concentration | n/a |
Applications | n/a |
Other Names | CK-2017357 |
Gene, Accession, CAS # | CAS: 1005491-05-3 |
Catalog # | 26075-50 |
Price | $272.00 |
Order / More Info | Tirasemtiv from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |