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Product Name | WYE-687 |
Description | An mTOR inhibitor (IC50 = 0.007 µM); selective for mTOR over PI3Kα and PI3Kγ (IC50s = 0.81 and 3.11 µM, respectively), as well as a panel of 24 additional kinases (IC50s = >50 µM for all); decreases phosphorylation of the mTORC1 and mTORC2 substrates Akt and S6K1, respectively, in a cell-free assay at 0.2, 1, and 5 µM; decreases proliferation of nine cancer cell lines (IC50s = 0.18-1.25 µM); inhibits survival of HL-60 and U937 leukemia cells; reduces tumor growth in a U937 mouse xenograft model at 5 and 25 mg/kg |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | WAY-687 |
Gene, Accession, CAS # | CAS: 1062161-90-3 |
Catalog # | 29977-10 |
Price | $278.00 |
Order / More Info | WYE-687 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |