XL335 from CAYMAN CHEMICAL COMPANY
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| Product Name | XL335 |
| Description | A potent and selective FXR agonist (EC50 = 4 nM in CV-1 cells transfected with human FXR); selective for FXR over a panel of 15 nuclear receptors at concentrations up to 10 µM; induces a 20-, 13-, and 2-fold increase in mRNA expression for IBABP, BSEP, and SHP, respectively, at a concentration of 1 µM; reduces plasma cholesterol and triglycerides and the area of pre-atherosclerotic lesions in LDLR-/- mice fed a Western diet; decreases hepatic fibrosis in a mouse model of non-alcoholic steatohepatitis |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | FXR 450|Turofexorate Isopropyl|WAY-362450 |
| Gene, Accession, CAS # | CAS: 629664-81-9 |
| Catalog # | 23350-10 |
| Price | $175.00 |
| Order / More Info | XL335 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY