ZLD1039 from CAYMAN CHEMICAL COMPANY
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| Product Name | ZLD1039 |
| Description | An inhibitor of EZH2 (IC50 = 5.6 nM); selective for EZH2 over EZH1 (IC50 = 81 nM) and is greater than 4,700-fold selective for EZH2 in a panel of 14 histone methyltransferases; inhibits mutant Y641F and A677G EZH2 (IC50s = 15 and 4 nM, respectively); inhibits methylation of H3K27 in MCF-7 breast cancer cells (IC50 = 0.29 µM) and decreases expression of CDH1, CDKN1C, CDKN2A, and RUNX3 in MCF-7 cells at 1 and 2 µM; suppresses migration of MCF-7 cells at 2 µM; reduces tumor growth in MCF-7 and MDA-MB-231 mouse xenograft models at 200 mg/kg, and inhibits tumor metastasis and decreases tumor protein levels of MMP-2, MMP-9, and E-cadherin in a 4T1 mouse xenograft model at 250 mg/kg |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | ZLD-1039 EZH 1 2 Y-641F Y641-F Y-641-F A-677G A677-G A-677-G H3K-27 H-3-K27 MCF7 CDH-1 1-C CDKN-1C 2A MDAMB-231 MDAMB231 MMP2 MMP9 4T-1 4-T-1 |
| Gene, Accession, CAS # | CAS: 1826865-46-6 |
| Catalog # | 19218-1 |
| Price | $81.00 |
| Order / More Info | ZLD1039 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY