Nilotinib (hydrochloride hydrate) from CAYMAN CHEMICAL COMPANY
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| Product Name | Nilotinib (hydrochloride hydrate) |
| Description | An inhibitor of wild-type and mutant Bcr-Abl (IC50s = 15 and 9-400 nM, respectively); selective for wild-type and mutant Bcr-Abl over Src and LYN (IC50s = >5,000 nM for both); inhibits Bcr-Abl autophosphorylation and cell proliferation in Ba/F3 cells expressing wild-type or mutant Bcr-Abl (IC50s = 7-155 and 13-51 nM, respectively); reduces midbrain Bcr-Abl autophosphorylation, amyloid-β levels, and neuronal loss, as well as improves autophagosome clearance and reverses cognitive deficits in the Tg2576 transgenic mouse model of Alzheimer's disease at 1 mg/kg; reduces serum creatine levels, renal profibrotic gene expression, and tubulointerstitial damage, as well as increases survival in a rat model of 5/6 nephrectomy-induced chronic kidney disease |
| Size | 1 g |
| Concentration | n/a |
| Applications | n/a |
| Other Names | 641571-10-0 AMN107 AMN-107 BcrAbl auto-phosphorylation Tg-2576 |
| Gene, Accession, CAS # | CAS: 923288-90-8 |
| Catalog # | 36628-1 |
| Price | $163.00 |
| Order / More Info | Nilotinib (hydrochloride hydrate) from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY