SGC0946 from CAYMAN CHEMICAL COMPANY
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| Product Name | SGC0946 |
| Description | A potent inhibitor of DOT1L (IC50 = 0.3 nM); over 100-fold selective over other PMTs; active in cells, reducing H3K79 dimethylation in A431 and MCF10A cells (IC50s = 2.6 and 8.8 nM, respectively) |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | methyltransferase epigenetic histone modification chromatin research inhibit inhibitor DOT1L protein PMTs enzyme methylate 3 three lysine 79 H3K79 catalyze monomethylation dimethylation trimethylation transcriptional gene DNA deoxyribonucleic acid damage repair cell cycle regulation A431 MCF10A bromine brominated analogs S-adenosylmethionine-competitive SAM-competitive EPZ004777 kills mixed lineages leukemia MLL cancers oncogenic fusion SGC 0946 Structural Genomic Consortium |
| Gene, Accession, CAS # | CAS: 1561178-17-3 |
| Catalog # | 13967-10 |
| Price | $182.00 |
| Order / More Info | SGC0946 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY