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Product Name | Avacopan |
Description | A C5a1 receptor antagonist (IC50 = 0.1 nM); selective for C5a1 over the C5a2 receptor and CMKLR2 (IC50s = >10,000 nM for both), as well as the C3a receptor, CMKLR1, and FPR1 (IC50s = >10,000 nM for all), and over panels of 18 chemokine receptors (IC50s = ≥6,700 nM for all), 54 other receptors at 10 µM, and five CYP isoforms (IC50s = >10,000 nM for all); reduces the migration of isolated cynomolgus monkey neutrophils at 50 nM; reduces C5a-induced increases in CD11b levels on neutrophils in isolated whole blood from human C5AR1 knock-in mice at 10 and 100 nM or at 0.075 and 0.15 mg/kg |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | CCX168 |
Gene, Accession, CAS # | CAS: 1346623-17-3 |
Catalog # | 36639-1 |
Price | $29.00 |
Order / More Info | Avacopan from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |