Description | A CDK inhibitor (IC50s = 7.6, 0.1, 19.8, 0.45, and 0.06 µM for Cdk1, -2, -4, -7, and -9, respectively); selective for CDKs over 10 additional kinases (IC50s = >100 µM for all) but does inhibit ERK2 (IC50 = 32 µM) and ABCB1(IC50 = 6.4 µM); inhibits proliferation of a variety of cancer cells, including those expressing wild-type p53 or mutant p53 (mean IC50s = 7.4 and 10.1 µM, respectively); inhibits replication of HSV-1, HSV-2, vaccinia virus, Ad4, and human CMV (IC50s = 5, 4.7, 3.8, 2.4, 3.2 µM, respectively) |