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Product Name | LY393558 |
Description | A serotonin reuptake inhibitor (IC50 = 3.3 nM in rat cortical synaptosomes); selective for serotonin reuptake over norepinephrine reuptake in rat cortical synaptosomes (IC50 = 2,510 nM); inhibits 5-HT-induced [35S]GTPγS binding in cells expressing human 5-HT1B or 5-HT1D receptors (Kbs = 0.89 and 10.4 nM, respectively); reduces pulmonary vascular remodeling, increases in right ventricular systolic pressure, and the development of right ventricular hypertrophy in a mouse model of pulmonary arterial hypertension at 30 mg/kg per day |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 388123-96-4 LY 393558 5HT 1B 1D 35 |
Gene, Accession, CAS # | CAS: 271780-64-4 |
Catalog # | 32775-10 |
Price | $164.00 |
Order / More Info | LY393558 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |