BMS 986165 from CAYMAN CHEMICAL COMPANY
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| Product Name | BMS 986165 |
| Description | An allosteric inhibitor of TYK2 (IC50 = 0.2 nM for the recombinant TYK2 pseudokinase domain); selective for TYK2 over a panel of 249 protein and lipid kinases at 1 µM but does inhibit the JAK1 pseudokinase domain and BMPR2 (IC50s = 1 and 193 nM, respectively); inhibits IFN-α-induced phosphorylation of STAT1, -2, -3, and -5 in PBMCs (IC50s = 1-6 nM); inhibits IL-12-induced production of IFN-γ in human PBMCs (IC50 = 11 nM) and IL-12-induced phosphorylation of STAT4 in NK-92 cells (IC50 = 5 nM); has anti-inflammatory effects in various mouse models |
| Size | 5 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | antiinflammatory BMS986165 TYK IL12 IL18 IFIT-3 IFIT-1 |
| Gene, Accession, CAS # | CAS: 1609392-27-9 |
| Catalog # | 33524-5 |
| Price | $202.00 |
| Order / More Info | BMS 986165 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
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