EP4 Receptor Antagonist 1 from CAYMAN CHEMICAL COMPANY
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| Product Name | EP4 Receptor Antagonist 1 |
| Description | An EP4 receptor antagonist (IC50 = 6.1 nm in a calcium flux assay); selective for EP4 over EP1, EP2, and EP3 receptors (IC50s = >10,000 nM for all); reverses PGE2-induced ERK phosphorylation in EP4-expressing CHO cells and decreases GM-CSF-induced expression of Il1b, Il4ra, Il6, Arg1, Cox2, and Il10 in RAW 264.7 cells at 10 µM; reduces tumor volume and increases infiltration of CD8+ T cells into tumors in a murine colon carcinoma model at 50 and 150 mg/kg once per day |
| Size | 1 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | EP 1 2 3 4 PGE 2 Gα 16 βarrestin HEK 293 GMCSF Il 1b 4ra 6 10 Arg 1 Cox 2 |
| Gene, Accession, CAS # | CAS: 2287259-07-6 |
| Catalog # | 32722-1 |
| Price | $68.00 |
| Order / More Info | EP4 Receptor Antagonist 1 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
Technical Support: techserv@caymanchem.com
Sales: sales@caymanchem.com
http://www.caymanchem.com
Profile of CAYMAN CHEMICAL COMPANY