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Product Name | Ro 48-8071 |
Description | An oxidosqualene cyclase inhibitor with cholesterol lowering activity; inhibits OSC from human liver microsomes and HepG2 cells (IC50s = ~6.5 and ~1.5 nM, respectively); lowered LDL cholesterol ~40% in hamsters without affecting HDL levels and no sign of liver toxicity at 150 µg/kg; increases cytochrome P3A mRNA and protein levels in primary rat and murine hepatocyte cultures at 30 µM |
Size | 10 mg |
Concentration | n/a |
Applications | n/a |
Other Names | monooxidosqualenes cyclases inhibitors OSC cholesterols lowering activity microsomal enzymes catalyzes lanosterol synthetic pathway LDL low-density lipoproteins human livers microsomes HepG2 cells HDL high-desity toxicity CYP3A mRNA proteins hepatocytes cultures atherosclerosis |
Gene, Accession, CAS # | CAS: 161582-11-2 |
Catalog # | 10006415-10 |
Price | $78 |
Order / More Info | Ro 48-8071 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |