Edit |   |
---|---|
Product Name | Ivacaftor |
Description | A CFTR potentiator; increases the forskolin-induced CFTR-mediated epithelial current in cells expressing the G551D missense mutation by ~4-fold (EC50 = 100 nM); increases chloride secretion in cultured human cystic fibrosis bronchial epithelial cells carrying the G551D mutation on one allele and the common ΔF508 processing mutation on the other allele; binds CFTR directly and leads to CFTR channel opening via an ATP-independent mechanism |
Size | 1 mg |
Concentration | n/a |
Applications | n/a |
Other Names | VX 770 |
Gene, Accession, CAS # | CAS: 873054-44-5 |
Catalog # | 15145-1 |
Price | $33.00 |
Order / More Info | Ivacaftor from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |