EMD 638683 from CAYMAN CHEMICAL COMPANY
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| Product Name | EMD 638683 |
| Description | An inhibitor of SGK1; inhibits SGK1 by 85% at 1 µM; >27-fold selective for SGK1 over a panel of 11 kinases, but does inhibit SGK2, SGK3, PRK2, and MSK1 by >50% at 1 µM; inhibits phosphorylation of the SGK1 target NDRG1 in HeLa cells (IC50 = 3.35 µM); increases radiation-induced apoptosis of Caco-2 colon carcinoma cells at 50 µM; dietary administration reduces the number of tumors in a mouse model of chemical carcinogenesis; prevents fructose and saline consumption-induced increases in systolic blood pressure in mice; decreases body weight, fasting blood glucose and HbA1c levels, and food intake in db/db diabetic mice; reduces angiotensin II-induced collagen deposition and cardiac fibrosis in mice |
| Size | 10 mg |
| Concentration | n/a |
| Applications | n/a |
| Other Names | EMD638683 SGK 1 2 3 PRK MSK NDRG Hb A1C |
| Gene, Accession, CAS # | CAS: 1181770-72-8 |
| Catalog # | 31117-10 |
| Price | $429.00 |
| Order / More Info | EMD 638683 from CAYMAN CHEMICAL COMPANY |
| Product Specific References | n/a |
CAYMAN CHEMICAL COMPANY
CAYMAN CHEMICAL COMPANY
1180 East Ellsworth Road
Ann Arbor MI 48108
P: (734) 971-3335
P: (800) 364-9897 (USA & Canada only)
F: (734) 971-3640
Customer Service: custserv@caymanchem.com
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