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Product Name | CP 105,696 |
Description | A LTB4 receptor antagonist (IC50 = 8.42 nM for the high-affinity receptor in human neutrophils); inhibits LTB4-induced chemotaxis in isolated human neutrophils (IC50 = 5 nM) and LTB4-induced calcium mobilization in isolated human monocytes (IC50 = 940 nM); reduces arachidonic acid-induced infiltration of neutrophils and eosinophils in guinea pig skin (ED50 = 0.3 mg/kg, p.o.); decreases blood glucose levels in the glucose tolerance test and reduces hepatic steatosis in a mouse model of obesity induced by a high-fat diet; decreases disease severity in a mouse model of EAE (ED50 = 8.6 mg/kg); increases graft survival in a mouse model of allogeneic heart transplantation at 50 mg/kg |
Size | 25 mg |
Concentration | n/a |
Applications | n/a |
Other Names | 186912-87-8 CP105696 LTB-4 |
Gene, Accession, CAS # | CAS: 158081-99-3 |
Catalog # | 17620-25 |
Price | $304.00 |
Order / More Info | CP 105,696 from CAYMAN CHEMICAL COMPANY |
Product Specific References | n/a |